+16 or trisomy 16 (solely)

+ 10 or trisomy 10 ( solely )

Clinics and pathology Disease ALL or ANLL. Phenotype / cell stem origin ALL cases are mostly pre B ALL; AML cases are M0, M1 or M2 AML, with, in most cases, a CD7+, CD33+ phenotype. Epidemiology Only 6 (poorly described) ALL cases and 9 ANLL cases, herein reviewed; incidence of +10: less than 1% of ANLL; sex ratio in ANLL cases is, so far, 1M/2F, and median age is 60 yrs (37-80 yrs), while ALL ...

Trisomy 16, cause of first trimester abortion.

Mitochondrial dysfunction in mouse trisomy 16 brain.

Mitochondrial function in the brain of mouse trisomy 16, an animal model of Down syndrome with accelerated neuron death, was studied in isolated cortex mitochondria. Using an oxygen-sensitive Clarke electrode, a selective 16% decrease in respiration was detected with the Complex I substrates malate and glutamate but not with the Complex II substrate succinate. Western blotting revealed a 20% de...

Partial trisomy 16 as a result of familial 16;20 translocation.

Although trisomy 16 is well recognised in spontaneous abortuses, it is infrequent in livebirths and there is little information about the clinical effects. We report two sibs with partial trisomy 16q resulting in infant death. Both children were severely growth retarded with small elfin faces, prominent foreheads, low set ears, abnormal external genitalia, and intractable diarrhoea.

Molecular studies of non-disjunction in trisomy 16.

The origin of the additional chromosome in 26 trisomy 16 spontaneous abortions was studied using DNA probes for chromosome 16, including a probe for centromeric alpha sequences. We were able to determine the parent and meiotic stage of origin of trisomy in 22 cases, with all being attributable to maternal meiosis I non-disjunction. Furthermore, in each of the remaining four cases the results we...